Endocrine Abstracts

Background: Recent data suggest that disturbances in circadian clock functioning are implicated in the pathogenesis of type 2 diabetes (T2D), through alterations in plasma glucose levels, insulin secretion and sensitivity, energy intake, and genomic expression in liver and pancreas. This study aimed to assess a potential association between variants in clock genes and T2D risk in a population of Greek elderly people.Methods: In a case-control design, 125...

Background: Vitamin D receptor (VDR) in the presence of active calcitriol (1.25--dihydroxy vitamin D) acts as a transcription factor that modulates the gene expression oftransport proteins, which are involved in calcium metabolism. Accumulating evidence suggest apotential implication of vitamin D deficiency in the pathogenesis of diabetes mellitus. We aimed toassess whether variants in the VDR gene contribute to risk of Type 2 Diabetes Mellitus (T2DM).<p class="ab...